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Table 2 Clinical Characteristics of NPM1-mutated AML Patients with Low or High INPP4B Expression

From: INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia

Characteristics Low INPP4B (n = 29) High INPP4B (n = 9)
Sex
 Female 15 6
 Male 14 3
Age, years
 Median, range 52.93 (21–81) 50.56 (21–82)
WBC, ×10 9 /L
 Median, range 61.58 (5–137) 49.78 (1–134)
Platelets, ×10 9 /L
 Median, range 53.86 (8–174) 63.56 (11–232)
Bone marrow blast, %
 Median, range 78.93 (48–98) 70.11 (41–95)
FAB classification
 M0 0 1
 M1 11 2
 M2 3 4
 M3 0 0
 M4 10 0
 M5 5 2
 M6 0 0
 M7 0 0
Cytogenetics
 Normal 27 7
 Abnormal 0 1
 Unknown 2 1
Cytogenetic risk
 Favorable 0 0
 Intermediate 28 7
 Adverse 0 1
 Unknown 1 1
Gene mutations
FLT3-ITD 16 6
IDH1 8 0
  1. Abbreviations: AML acute myeloid leukemia, WBC white blood cell, FAB classification, French-American-British classification, a classification of acute leukemia produced by three-nation joint collaboration