Table 2 Clinical Characteristics of NPM1-mutated AML Patients with Low or High INPP4B Expression
From: INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia
Characteristics | Low INPP4B (n = 29) | High INPP4B (n = 9) |
|---|---|---|
Sex | ||
 Female | 15 | 6 |
 Male | 14 | 3 |
Age, years | ||
 Median, range | 52.93 (21–81) | 50.56 (21–82) |
WBC, ×10 9 /L | ||
 Median, range | 61.58 (5–137) | 49.78 (1–134) |
Platelets, ×10 9 /L | ||
 Median, range | 53.86 (8–174) | 63.56 (11–232) |
Bone marrow blast, % | ||
 Median, range | 78.93 (48–98) | 70.11 (41–95) |
FAB classification | ||
 M0 | 0 | 1 |
 M1 | 11 | 2 |
 M2 | 3 | 4 |
 M3 | 0 | 0 |
 M4 | 10 | 0 |
 M5 | 5 | 2 |
 M6 | 0 | 0 |
 M7 | 0 | 0 |
Cytogenetics | ||
 Normal | 27 | 7 |
 Abnormal | 0 | 1 |
 Unknown | 2 | 1 |
Cytogenetic risk | ||
 Favorable | 0 | 0 |
 Intermediate | 28 | 7 |
 Adverse | 0 | 1 |
 Unknown | 1 | 1 |
Gene mutations | ||
 FLT3-ITD | 16 | 6 |
 IDH1 | 8 | 0 |