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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway

Fig. 5

STIP1 was associated with the activation of Wnt/β-catenin signaling pathway. a Knock-down of STIP1 markedly reduced the expressions of p-GSK-3β(Ser9), β-catenin, p-β-catenin(Tyr654), c-Myc, and CyclinD1 by Western blot (Left). Overexpression of STIP1 significantly increased the expressions of p-GSK-3β(Ser9), β-catenin, p-β-catenin(Tyr654), c-Myc, and CyclinD1 by Western blot (Right). b Knocked down of STIP1 decreased nuclear β-catenin expression and increased cytosolic β-catenin expression by Western blot (Left). Overexpression of STIP1 increased nuclear β-catenin expression and decreased cytosolic β-catenin expression by Western blot (Left). c β-catenin nuclear translocation was detected by IF staining

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