Skip to main content
Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: RETRACTED ARTICLE: miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3

Fig. 3

miR-3928v directly targets the 3′UTR of VDAC3 mRNA. a The predicted miR-3928v binding site in the VDAC3 3′UTR and the introduced mutations in the binding site (VDAC3 mut) (left). Dual-luciferase reporter assays were performed to analyze the effect of miR-3928v on the VDAC3 3′UTR (right). # indicates no statistically significant difference. b RT-qPCR (left) and Western blot (right) were performed to examine VDAC3 mRNA and protein expression levels after miR-3928v overexpression or inhibition in HCC cells. c-d The relative VDAC3 mRNA level was determined in HCC cells (c) and tissues (d). e Representative IHC images showing the magnitude of VDAC3 expression in tissues isolated from liver cancer patients (left) and nude mice (right). f VDAC3 mRNA level in tissues isolated from nude mice. (*: P < 0.05, **: P < 0.01)

Back to article page