Fig. 7From: RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1Schematic illustration of the proposed mechanism by which RHBDD1 promotes metastasis in colorectal cancer. RHBDD1 activates Wnt-signaling pathway activity mainly through increasing p552-β-catenin and p675-β-catenin to promote cell EMT and stemness. Meanwhile, RHBDD1 increases ZEB1 expression. ZEB1 is a potent EMT activator and can regulate cell stemness. Thus, EMT and stemness promote colorectal cancer metastasisBack to article page