Fig. 2

14, 15-EET up-regulates integrin αvβ3 expression and activates FAK/PI3K/AKT signaling. MCF-7 and MDA-MB-231 cells were untreated or treated with 14, 15-EET (100 nM) and/or 14, 15-EEZE (200 nM). a and b The expression of integrin αvβ3 was analyzed by real-time RT-PCR and Western blot. c The phosphorylated and un-phosphorylated FAK, PI3K and AKT were detected by Western blot. *p < 0.05, **p < 0.01