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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

Fig. 4

14, 15-EET induces breast cancer cells EMT via integrin αvβ3 and FAK/PI3K/AKT signaling. MCF-7 and MDA-MB-231 cells were untreated or treated with 14, 15-EET (100 nM) and/or 14, 15-EEZE (200 nM). a 14,15-EET induces mesenchymal morphology changes in MCF-7 and MDA-MB-231 cells: spindle shape and loss of cell-cell contact. b EMT markers in tumor cells were examined by Western blot. The integrin αv or β3 knockdown tumor cells were untreated or treated with 14, 15-EET (100 nM). c EMT markers in tumor cells were examined by Western blot. Tumor cells were untreated or treated for 30 min with PF562271 (100 nM) or LY294002 (500 nM) followed by stimulation with 14, 15-EET (100 nM). d EMT markers in tumor cells were examined by Western blot

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