Fig. 5

14, 15-EET induces cisplatin resistance in breast cancer cells. MCF-7 and MDA-MB-231 cells were untreated or treated with 14, 15-EET (100 nM) and/or 14, 15-EEZE (200 nM). a The sensitivity of tumor cells to cisplatin was determined by MTT assay. The integrin αv or β3 knockdown tumor cells were untreated or treated with 14, 15-EET (100 nM). Tumor cells were untreated or treated with PF562271 (200 nM) or LY294002 (500 nM) followed by stimulation with 14, 15-EET (100 nM). b and c The sensitivity of tumor cells to cisplatin was determined by MTT assay. *p < 0.05