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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

Fig. 1

ECM alteration is associated with the tumorigenesis and progression of human ovarian cancer. (a) Col1a1, Col1a2, FN1 and LOX transcript expression levels in normal ovary and ovarian cancer tissues in published TCGA data (Oncomine). Center line represents median values, box limits are the 25th and 75th percentiles, and whiskers represent the minimum and maximum values. (b, c) Kaplan-Meier analyses of the 3-year OS (b) and PFS (c) in ovarian cancer patients according to Col1a1, Col1a2, FN1 and LOX expression levels. These data were dichotomized at the median value into high and low expressing groups. (d) Representative images of H&E staining exhibit the histology of paired primary and metastatic lesions from ovarian cancer patients. The dashed line (green) delimits the tumor tissues. T represents tumor. (e) Representative images and positive-stained percentage of Masson’s Trichrome (left) and Picrosirius Red (right) staining of primary lesions and metastases from ovarian cancer patients. Bar represents 50 μm

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