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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

Fig. 3

The remodeled peritoneal microenvironment accelerates ovarian cancer progression. (a) Flowchart of the in vivo experiments. (b) Luciferase bioluminescence was determined in WT and ApoE−/− mice two weeks after ID8 allografts engraftment. Graph represents the mean radiance for each group (n = 5). (c) The omentum, peritoneum and diaphragm of WT and ApoE−/− mice were excised and analyzed under a fluorescence microscope (left). The number and weight of the tumor lesions were measured (right). Bar represents 200 μm. (d) The tumor burden was assayed by the abdominal circumference and ascetic fluid content. (e) Representative images (left) and quantification (right) of tumor lesions dispersed in the diaphragm, omentum and mesentery. Dashed circles delimit the tumor tissues. (f) Survival rate of WT and ApoE−/− mice with ID8 allografts. Error bars represent the SD of the experimental data from five mice. *P < 0.05; **P < 0.005

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