Fig. 6

Triptolide suppressesed the transcription of c-Myc through targeting ERCC3. a Triptolide treatment showed a decrease in ERCC3 levels. b Relative mRNA (left panel) and protein expression (right panel) of ERCC3 and c-Myc in ERCC3/c-MYC-silenced and overexpressed HepG2 cells. c Over-expression of ERCC3 counteracted triptolide-induced c-Myc inhibition. d Over-expression of ERCC3 and c-Myc protected HepG2 cells from triptolide induced apoptosis. e The protein expression of ERCC3 and c-Myc was elevated in most of HCC cell lines tested