Fig. 4

The cellular toxicity of two kinds of nano-carriers in vitro

. Notes: (a) The toxicity of the blank PEG-PLA-NP to SK-OV-3 cells. Up to the concentration of 100 μg/ml, blank nano-carriers did not inhibit the SK-OV-3 cells viability significantly; (b) The cellular inhibition rate in different groups. PTX-PEG-PLA-FA-NP showed significantly more toxicity against SK-OV-3 cells at multiple dosages than PTX-PEG-PLA-NP as well as free PTX based on the equivalent PTX concentrations (p < 0.05). (c)The toxicity to SK-OV-3 cells under different co-incubation intervals. *p < 0.05, **p < 0.01, ***p < 0.001 vs PTX. ^#p < 0.05, ^{# #}p < 0.01, ^{# # #}p < 0.001 vs PTX-PEG-PLA-NP