Fig. 5

The tissues distributions of PTX in different groups in tumor bearing mice. Notes: The PTX levels in different tissues at various time points after three kinds of PTX solutions administration. (a) plasma; (b) lung tissues; (c) liver tissues; (d) small intestine tissues; (e) uterus tissues; (f) kidney tissues; (g) spleen tissues; (h) heart tissues; (i) PTX levels of different groups in different tissues at 6 h. The PTX concentrations at 6 h in different tissues were much higher in the nano-carriers groups than in the free PTX group. The PTX concentration tumor tissues and reticuloendothelial system in PTX-PEG-PLA-FA-NP group were higher than that of other two groups. *p < 0.05, **p < 0.01, ***p < 0.001 vs PTX. ^#p < 0.05, ^{# #}p < 0.01, ^{# # #}p < 0.001 vs PTX-PEG-PLA-NP