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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

Fig. 8

APG-1387 inhibits tumor growth in xenografted ovarian models. a, b Changes in tumor volume and tumor growth between APG-1387 (1, 3, 10 mg/kg) group and vehicle group of SKOV3 tumor-bearing mice. Data are shown as mean tumor volume ± SD (eight mice/group). c, e, d, f Mice bearing SKOV3 xenograft tumor were treated with a single intravenous dose of APG-1387 and tumors were collected at the indicated time points for western blot analysis (Group 1: c, e and Group 1: d, f) or TUNEL assay (g, h). For western blot analysis, tumor lysates were assigned into two groups (Group 1: c, e and Group 1: d, f) and analyzed for the indicated proteins. g, h IHC staining assay (testing TUNEL-positive cells). All values were expressed as mean ± SD. *p < 0.05 vs. group of “control”. Bar ¼ 100 mm

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