Fig. 6

Reduced of CDK2 expression suppressed the cell proliferation induced by WTAP in RCC cells. a, b) CCK8 and clone formation assays were used to measure the effect of CDK2 small interference RNA (siCDK2) on Caki-1 and ACHN cells with WTAP overexpression. c, d) The effect of CDK2 inhibitors (SU9516 and K03861) on Caki-1 and ACHN cells with WTAP overexpression were measure by CCK8 and clone formation assays. The fold change (NC/WTAP) was stated under the histogram. Data represent the mean ± SD from three independent experiments,*P < 0.05