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Table 1 Potential LIR Motif in ALK

From: The potential role of HGF-MET signaling and autophagy in the war of Alectinib versus Crizotinib against ALK-positive NSCLC

No Position Domain Type Sequence
1 46–49 Extracellular Y YSRL
2 253–256 Extracellular F FPFL
3 290–293 MAM1 W WRRI
4 320–323 MAM1 F FLLL
5 386–389 MAM1 W WTVL
6 419–422 MAM1 F FFAL
7 587–590 MAM2 Y YEGL
8 595–598 MAM2 W WMVL
9 625–628 MAM2 F FDNI
10 635–638 MAM2 Y YLTI
11 772–775 Extracellular Y YILV
12 1052–1055 TM F FSGI
13 1127–1130 PTK F FGEV
14 1193–1196 PTK F FILL
15 1315–1318 PTK F FGVL
16 1376–1379 PTK F FAII
17 1401–1404 Intracellular Y YGPL