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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer

Fig. 4

Blockade of TIM3 reduced the number of TIM3+ Tregs. a The tumor growth curve of each group. b Percent of TIM3+ cells from the draining lymph node (LN) and spleen (SP) in the anti-TIM3 therapy group (n = 6) and control group (n = 6). c CD4+ T cells were gated from CD25+ Foxp3+; then, TIM3+ cells in CD4+CD25+Foxp3+ Treg population was assessed. d Percent of CD25+Foxp3+ Tregs in the CD4+ T cell population from LN and SP of anti-TIM3 therapy group (n = 6) and control group (n = 6). e Percent of TIM3+ cells in the CD4+CD25+Foxp3+ Treg population (mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, Mann-Whitney test)

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