From: CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (years) | ||||||
< 65 vs. ≥ 65 | 0.94 | 0.55–1.59 | 0.809 | |||
Gender | ||||||
Male vs. Female | 0.73 | 0.36–1.48 | 0.377 | |||
Tumor size (mm) | ||||||
< 50 mm vs. ≥50 mm | 1.58 | 1.13–2.71 | 0.043 | 0.861 | 0.48–1.55 | 0.616 |
Histology | ||||||
Well/Moderately vs. Poor | 1.59 | 1.22–2.72 | 0.045 | 1.129 | 0.64–1.98 | 0.674 |
Tumor location | ||||||
Upper vs. Middle vs. Low vs. ≥2 regions | 0.84 | 0.64–1.11 | 0.219 | |||
Depth of invasion | ||||||
pT1 vs. pT2 vs. pT3 vs. pT4 | 3.47 | 2.01–5.97 | <0.001 | 2.57 | 1.50–4.40 | 0.001 |
Lymph node metastasis | ||||||
pN0 vs. pN1 vs. pN2 vs. pN3 | 2.59 | 1.74–3.85 | <0.001 | 2.16 | 1.38–3.38 | 0.001 |
Distant metastasis | ||||||
pM0 vs. pM1 | 6.94 | 3.42–14.07 | <0.001 | 3.34 | 1.54–7.23 | 0.002 |
CDK5RAP3 expression | ||||||
Low vs. High | 0.84 | 0.72–0.97 | 0.014 | 0.89 | 0.78–0.98 | 0.035 |
p-AKT(Ser473) expression | ||||||
Low vs. High | 4.17 | 2.10–8.28 | <0.001 | 3.99 | 1.97–8.08 | <0.001 |