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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Fig. 5

An inverse correlation between miR-1468 and CITED2, UPF1 expression is observed in HCC tissues. a and b The expression of CITED2 and UPF1 in miR-1468 high-expressing tumors was significantly lower than that in miR-1468 low-expressing tumors, as determined by qRT-PCR and immunoblotting. c An inverse correlation between the levels of miR-1468 and CITED2, UPF1 mRNA was observed in HCC tissues. d Representative immunohistochemical staining showed a weak staining of CITED2, UPF1 in miR-1468 high-expressing HCC tissue and strong staining of CITED2, UPF1 in the miR-1468 low-expressing tumor. The adjacent nontumor tissues show a stronger staining of CITED2 and UPF1 compared to HCC tissues. e The expression of CITED2 and UPF1 were down-regulated in HCC tissues compared with matched non-tumor tissues. f Xenografts tissues immunohistochemical staining of CITED2 and UPF1 in miR-1468 overexpression or knockdown subcutaneous tumor nodules. *P < 0.05

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