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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Fig. 6

Modulation of CITED2 or UPF1 partially abolishes miR-1468-mediated cellular processes in HCC. a miR-1468-overexpressing Hep3B cells that were transfected with empty vector (EV) or CITED2, UPF1 overexpression plasmid were subjected to western blot for CITED2 and UPF1. miR-1468-suppressive MHCC-97 L cells that were transfected with scrambled siRNA or CITED2, UPF1 siRNA were subjected to western blot for CITED2, UPF1. CITED2 or UPF1 restoration abrogated the effects of miR-1468 overexpression on cell proliferation (b, c), colony formation (d), cell cycle progression (e) and apoptosis (f) of Hep3B cells. CITED2 or UPF1 knockdown reversed the suppressive effects of miR-1468 knockdown in MHCC-97 L cells (b-f). g Alteration of CITED2 or UPF1 abolished the effects of miR-1468 on cell cycle and apoptosis associated factors. *P < 0.05

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