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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Fig. 8

AKT phosphorylation is essential for the biological function of miR-1468 in HCC. AKT inhibitor MK2206, or AKT phosphorylation activator IGF-1, abolished the cell proliferation (a, b), colony formation (c), cell cycle progression (d) and apoptosis (e) of HCC cells which were transduced of miR-1468 vectors. f Western blot analysis indicated that modulating AKT phosphorylation reversed the effects of miR-1468 alteration on cell cycle and apoptosis associated factors of HCC cells. *P < 0.05

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