Fig. 6

OGN consistently reduced tumor growth and liver metastasis in vivo. Equal numbers of OGN-over-expressing SW620 or their corresponding control counterparts were injected into nude mice. a1 Representative photographs of tumor at the end of study. Tumors weight (a2) and tumor volumes (a3) were measured on the indicated days. IHC study showed strong E-cadherin (b), but weak Zeb-1(c) staining in OGN over-expressing tumors than its control group. d1 The gross images of liver metastases observed in the nude mice injected with SW620 cells. Red arrows represent metastatic tumors. d2 H&E staining for the liver metastases. e Schematic model depicts how OGN inhibits EMT through the EGFR/Akt signaling pathway