Treatmenta | Regressionb | Stable diseaseb | Progressionb |
|---|
EMICORON | 0/5 | 1/5 | 4/5 |
FOLFIRI | 1/5 | 3/5 | 1/5 |
FOLFIRI plus EMICORON | 3/5 | 2/5 | 0/5 |
- aTumor fragments derived from passage 1, were coated in Matrigel and implanted s.c. in mice (15–20 mm3/mouse) as described in the legend of fig. 2. When the tumor mass reached about 250 to 300 mm3, treatment started by giving mice FOLFIRI regimen consisting in Irinotecan (CPT-11) i.p. at 15 mg/kg for five consecutive days, followed by 5-Fluorouracil (5-FU) i.p. at 19 mg/kg plus Leucovorin at 20 mg/kg for five consecutive days. EMICORON was administered per os at 15 mg/kg for the next seven days. Five mice were included in each experimental group
- bRegression or stable disease were considered when was observed the reduction or the maintenance, respectively, of the same tumor weight for at least two weeks after the starting of treatment
