Fig. 2
From: Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
PTX008 inhibits binding of Galectin-1 to the surface of ALL cells. LAX56 cells (2 × 104) were plated without OP9 stroma and treated for 1 h with DMSO or 10 μM PTX008. The ability of human recombinant Galectin-1 or human recombinant GST-Galectin-3 or control GST to cause agglutination of the LAX56 cells was then quantitated by light microscopy. a Representative images of cells. Left two panels show controls of cells incubated with GST only or DMSO only. b quantification of number of aggregates in each condition. (*p < 0.05)