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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

Fig. 3

Galectin-1-mediated adhesion to fibronectin is inhibited by PTX008. a-c Representative analysis of (a) US7, (b) LAX56 or (c) LAX57 cells adhering to fibronectin (left panels) or poly-L-lysine coated plates (middle panels) in the presence of increasing concentrations of PTX008 or 5 and 50 mM lactose. Error bars: standard deviation. Cell surface staining using FACS (Genetex antibodies) for Galectin-1 on these samples (right panels). Numbers, percentage of cells in the upper left quadrants. *p≤0.05 (95% CI, 1-way ANOVA). d Summary fold difference in adhesion of LAX56 and LAX57 to fibronectin and poly-L-lysine coated plates. Percent adhesion was normalized to DMSO control for 3 replicate experiments with 3 or more replicate wells. Error bars, standard error of mean (**p<0.01, 1-way ANOVA)

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