Fig. 7
From: Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
Treatment with PTX008 and vincristine reduces leukemia burden in mice. NSG mice on d7 after transplant with 2 × 106 primary LAX57 ALL cells were treated with vehicle control; 5 mg/kg PTX008 5× per week; 0.5 mg/kg vincristine 1×/ week and 5 mg/kg PTX008 plus 0.5 mg/kg vincristine for 28 days. All mice were euthanized when PBS vehicle control mice exhibited ≥ 10% loss in body weight as compared to the previous day. a-c Percent of human (h) CD19+ leukemia, murine (m) Ly-6G granulocytes, murine monocyte/dendritic cells, murine/human monocytes, and murine/human Galectin-1 found within (a) the bone marrow, (b) spleen, (c) peripheral blood at the end of the treatment period. d Percent of human CD19+ leukemia cells in the spleen of control and treated mice (**, p<0.01, ***, p<0.001, 95% CI, 2-way ANOVA)