Fig. 7From: Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasisA schematic of radiotherapy induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis. Radiotherapy induced the cancer cells’ death. HMGB1 is released by dying cells and binds specific receptor TLR2. HMGB1/TLR2 stimulates phosphorylation of PI3K/Akt and EMT in a paracrine manner, which promotes the metastasis of cancer cells to the lungBack to article page