Fig. 3
From: miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
Dock6 promotes GC migration and invasion by activating Rac1 and Cdc42. a GST pull-down and western blot analyses of the expression of Dock6 and the activation state and total expression of Rac1/Cdc42 in the indicated cells. b A Rac1 inhibitor (NSC23766, 50 μM) and Cdc42 inhibitor (ML141, 20 μM) could block Dock6-mediated cell migration and invasion as detected by transwell studies. Scale bars, 50 μm. c Wound healing assays were used to evaluate the migration of the indicated cells