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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

Fig. 4

miR-141 reversed the tumor growth suppressive effect of c-Myc knockdown in vivo. a Tumor growth curve (left panel) and images (right panel) of the 5-8F xenograft model in nude mice. b Tumor weight quantification (left panel) and images (right panel) (N = 5). c Western blotting and d qRT-PCR assays confirmed the expression of c-Myc and miR-141 in xenografts, respectively. β-actin and U6 served as internal controls, respectively. e IHC (DAB staining) for quantification of the proliferation marker Ki67 (right panel) and images (left panel) and f TUNEL (DAB staining) for quantification of apoptosis (right panel) and images (left panel). e and f Original magnification, 200×; the scale bars represent 50 μm. a, b, d, e and f The error bars represent the mean ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001

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