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Table 1 Association between the expression of c-Myc, BRD7, miR-141 and NPC clinical pathological features (N = 41)

From: BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

 

c-Myc

BRD7

miR-141

Characteristics (N)

H (%)

L (%)

P

H (%)

L (%)

P

H (%)

L (%)

P

Age (year)

  ≤ 40 (n = 7)

3(42.8)

4(57.2)

0.6786

1(14.2)

6(85.8)

0.4942

4(57.1)

3(42.9)

0.7052

  > 40 (n = 34)

20(58.8)

14(41.2)

 

9(26.4)

25(73.6)

 

22(64.7)

12(35.3)

 

Gender

 Female (n = 9)

6(66.6)

3(33.4)

0.7061

2(22.2)

7(77.8)

0.8639

8(88.8)

1(11.2)

0.0725

 Male (n = 32)

17(53.1)

15(46.9)

 

8(47.1)

24(52.9)

 

18(56.2)

14(43.8)

 

Histological type

 DNC (n = 20)

12(60.0)

8(40.0)

0.7557

5(25.0)

15(75.0)

0.9293

14(70.0)

6(30.0)

0.3929

 UDNC (n = 21)

11(52.3)

10(47.7)

 

5(23.8)

16(76.2)

 

12(57.1)

9(42.9)

 

Clinical stage

 Stage I (n = 7)

1(14.2)

6(85.8)

0.0140

4(57.1)

3(42.9)

0.0475

2(28.6)

5(71.4)

0.0246

 Stage II (n = 19)

10(52.6)

9(47.4)

 

2(10.5)

17(89.5)

 

11(57.8)

8(42.2)

 

 Stage III-IV (n = 15)

12(80.0)

3(20.0)

 

4(26.6)

11(73.4)

 

13(86.6)

2(13.4)

 
  1. Abbreviations: DNC, differentiated non-keratinized nasopharyngeal carcinoma; UDNC, undifferentiated non-keratinized nasopharyngeal carcinoma; H, high expression; L, low expression