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Table 2 Univariate and multivariable analyses of factors predictive of poor overall survival in pancreatic cancer patients

From: MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Variables

Univariate analysis

Multivariate analysis

Overall survival

95% confidence interval

P value

Hazard ratio

95% confidence interval

P value

(Median ± SE,months)

Gender

  

0.342

0.675

0.397-1.148

0.147

 Male

23.685 ± 3.702

16.430-30.941

    

 Female

24.640 ± 3.679

17.430-31.850

    

Age(years old)

  

0.653

0.999

0.616-1.622

0.997

 <65

26.863 ± 3.838

19.339-34.386

    

  ≥ 65

20.155 ± 3.405

13.482-26.828

    

Locations

  

0.576

1.109

0.659-1.868

0.696

 Head

27.543 ± 3.832

20.032-35.054

    

 Body-tail

22.933 ± 4.641

13.837-32.029

    

Perineuronal invasion

  

0.645

1.155

0.668-1.998

0.605

 No

27.687 ± 4.269

19.320-36.054

    

 Yes

24.122 ± 4.181

15.928-32.316

    

Tumor staging

  

0.173

0.568

0.185-1.742

0.322

 T1/T2

28.275 ± 3.560

21.298-35.253

    

 T3/T4

17.824 ± 4.633

8.743-26.904

    

Lymph node staging

  

0.005

0.631

0.194-2.049

0.443

N0

33.336 ± 4.398

24.715-41.956

    

N1

14.520 ± 2.408

9.801-19.240

    

TNM staging

  

0.000

4.501

1.253-16.161

0.021

 I

40.521 ± 5.492

29.757-51.286

    

 II

15.706 ± 2.506

10.795-20.618

    

Diabetes

  

0.717

1.808

0.895-3.652

0.099

 No

25.790 ± 3.315

19.294-32.287

    

 Yes

22.350 ± 5.087

12.379-32.321

    

MiR-10a expression

  

0.020

2.878

1.614-5.131

0.000

 Low

35.489 ± 5.446

24.814-46.164

    

 High

20.195 ± 3.316

13.697-26.694

    

TFAP2 expression

  

0.039

0.46

0.261-0.809

0.007

 Low

19.367 ± 3.568

12.373-26.360

    

 High

32.159 ± 4.539

23.263-41.055

    
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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