Fig. 6
Knockdown of YAP in PCs suppresses tumor growth and desmoplastic reaction in vivo. a Cell mixtures containing BxPC-3-shNC, BxPC-3-shYAP, BxPC-3-shNC+PSCs and BxPC-3-shYAP+PSCs were implanted subcutaneously into the flank of BALB/c nude mice. Representative photographs of BxPC-3-shNC, BxPC-3-shYAP, BxPC-3-shNC+PSC, and BxPC-3-shYAP+PSC co-implantation mice bearing xenograft tumors. b Tumor volumes were determined by measuring the width and length of the tumors every week. Mean (n = 5); bars, SD. c Representative images of hematoxylin and eosin (HE staining and immunostaining for PCNA and α-SMA in tumor tissues from mice subcutaneously injected with pancreatic cancer cells (bar, 100 μm)