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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2

Fig. 1

Expression of GDF15 in samples of normal cervix and various cervical lesions. Immuno-histochemical (IHC) detection of GDF15 in normal cervix(NC), high-grade squamous intraepithelial lesion(HSIL) and squamous cervical cancer(SCC) samples (a); original magnification, 400×. GDF15 staining was classified into 2 categories, negative and positive (b), and the bar chart shows the percentage of each group (21 NC specimens, 23 HSIL specimens, and 32 SCC specimens). The scatter plot illustrates the immunoreactivity scores obtained for GDF15 staining in NC, HSIL and SCC samples (c), points represent the IHC score per specimen, and one-way ANOVA was performed. The expression of GDF15 in normal cervix (NC) and squamous cervical carcinoma (SCC) samples was detected by western blotting (d). The relative expression of GDF15 in each sample of NC (n = 8) and SCC (n = 10) is shown (e). The data are shown as the ratios of GDF15/β-actin of each specimen and as the means ± standard error of the NC and SCC groups. Values are shown as the mean ± SD, *p < 0.05, **p < 0.01

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