Fig. 2
From: The dysregulation of tRNAs and tRNA derivatives in cancer
The overexpression of tRNAs regulated the progression of cancer acting on different ways: Ras, c-myc and TERT promoted the transcription of tRNA genes by binding to pol III. a The overexpression of tRNA activated the RSK1/MSK2 signaling pathway, thus influencing cell proliferation and cell apoptosis. b Overexpressed tRNA promoted the ability of invasion and metastasis by enhancing stability and translation of transcripts enriched for their cognate codons. c The overexpression of tRNA regulated the progression of cancer by increasing the secretion of integrin and type II collagen