Fig. 2

SPIN1 increased breast cancer resistance to Adriamycin in vitro and in vivo. a SPIN1 overexpression plasmid transfection increased, whereas SPIN1 siRNA transfection decreased, SPIN1 mRNA expression in breast cancer cells. b, d Overexpression of SPIN1 enhanced chemoresistance in MCF-7/ADM and MCF-7 cells. c, e Downregulation of SPIN1 increased chemosensitivity in MCF-7/ADM and MCF-7 cells. f Tumors originating from MCF-7/ADM cells expressing miRNA against SPIN1 (SPIN1-low) were significantly smaller in size than those originating from control (SPIN1-high) cells (^**P < 0.01, ^***P < 0.001)