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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

Fig. 1

hTERT alternative splice variant patterns in human gliomas and cell lines. a Two main alternative splicing sites: the α splice site in exon 6, which produces a 36-bp in frame deletion; and the β splice site in exon 7 and exon 8, which results in a 182-bp deletion and nonsense mutation that truncates the protein. hTERT variant patterns of cell lines (b) and human gliomas including 38 GBMs (c), 24 ODMs (d) and 35 OAMs (e) were investigated by RT-PCR (Only a representative portion of the total analyzed samples was shown in the gels). Two hTERT alternative splice variants (hTERT+β and hTERT–β) were detected in subsets of the tumors and cell lines. Thirty-three of 38 (86.8%) GBMs, 17 of 24 (73.9%) ODMs and 15 of 35 (42.9%) OAMs exhibited hTERT+β transcript, and the remaining 31 cases only exhibited hTERT–β transcript. Accordingly, cases with hTERT +β transcript were consistent with the expression of hTERT-FL transcript

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