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Table 1 Characteristics of glioma patients according to TA and hTERT transcript

From: Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

Characteristics

n patients (%)

TA, n patients

(%)

P

hTERT, n patients

(%)

P

n = 96

Positive

67 (69.8)

Negative

29 (30.2)

hTERT +β

65 (67.7)

hTERT -β

31 (32.3)

Gender

   

1

  

1

 Male

51 (53.1)

36 (70.6)

15 (29.4)

 

35 (68.6)

16 (31.4)

 

 female

45 (46.9)

31 (68.9)

14 (31.1)

 

30 (66.7)

15 (33.3)

 

Age

   

0.007*

  

0.029*

 <50

52 (54.2)

30 (57.7)

22 (42.3)

 

30 (57.7)

22 (42.3)

 

  ≥ 50

44 (45.8)

37 (84.1)

7 (15.9)

 

35 (79.5)

9 (20.5)

 

KPS

   

0.012*

  

0.015*

 <75

57 (59.4)

34 (59.6)

23 (40.4)

 

33 (57.9)

24 (42.1)

 

  ≥ 75

39 (40.6)

33 (84.6)

6 (15.4)

 

32 (82.1)

7 (17.9)

 

Tumor size (cm)

   

0.008*

  

0.002*

 <6

49 (51)

28 (57.1)

21 (42.9)

 

26 (53.1)

23 (46.9)

 

  ≥ 6

47 (49)

39 (83)

8 (17)

 

39 (83)

8 (17)

 

Histopathology and WHO grade

   

0.001*

  

0.001*

 GBMs (IV)

38 (39.6)

34 (89.5)

4 (10.5)

 

33 (86.8)

5 (13.2)

 

 ODMs (III)

23 (24)

17 (73.9)

6 (26.1)

 

17 (73.9)

6 (26.1)

 

 OAMs (III, II)

35 (36.4)

16 (45.7)

19 (54.2)

 

15 (42.9)

20 (57.1)

 

Extent of resection

   

0.082

  

0.334

 GTR

71 (74)

46 (64.8)

25 (35.2)

 

46 (64.8)

25 (35.2)

 

 STR

25 (26)

21 (84)

4 (16)

 

19 (76)

6 (24)

 
  1. *P-values indicating significance; KPS Karnofsky Performance Score, GTR Gross-total Resection; STR Subtotal Resection