Skip to main content

Table 1 Characteristics of glioma patients according to TA and hTERT transcript

From: Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

Characteristics n patients (%) TA, n patients
(%)
P hTERT, n patients
(%)
P
n = 96 Positive
67 (69.8)
Negative
29 (30.2)
hTERT +β
65 (67.7)
hTERT -β
31 (32.3)
Gender     1    1
 Male 51 (53.1) 36 (70.6) 15 (29.4)   35 (68.6) 16 (31.4)  
 female 45 (46.9) 31 (68.9) 14 (31.1)   30 (66.7) 15 (33.3)  
Age     0.007*    0.029*
 <50 52 (54.2) 30 (57.7) 22 (42.3)   30 (57.7) 22 (42.3)  
  ≥ 50 44 (45.8) 37 (84.1) 7 (15.9)   35 (79.5) 9 (20.5)  
KPS     0.012*    0.015*
 <75 57 (59.4) 34 (59.6) 23 (40.4)   33 (57.9) 24 (42.1)  
  ≥ 75 39 (40.6) 33 (84.6) 6 (15.4)   32 (82.1) 7 (17.9)  
Tumor size (cm)     0.008*    0.002*
 <6 49 (51) 28 (57.1) 21 (42.9)   26 (53.1) 23 (46.9)  
  ≥ 6 47 (49) 39 (83) 8 (17)   39 (83) 8 (17)  
Histopathology and WHO grade     0.001*    0.001*
 GBMs (IV) 38 (39.6) 34 (89.5) 4 (10.5)   33 (86.8) 5 (13.2)  
 ODMs (III) 23 (24) 17 (73.9) 6 (26.1)   17 (73.9) 6 (26.1)  
 OAMs (III, II) 35 (36.4) 16 (45.7) 19 (54.2)   15 (42.9) 20 (57.1)  
Extent of resection     0.082    0.334
 GTR 71 (74) 46 (64.8) 25 (35.2)   46 (64.8) 25 (35.2)  
 STR 25 (26) 21 (84) 4 (16)   19 (76) 6 (24)  
  1. *P-values indicating significance; KPS Karnofsky Performance Score, GTR Gross-total Resection; STR Subtotal Resection