Fig. 3

MET signaling inhibition attenuated the invasion and metastasis-promoting effects induced by VEGF inhibition in hepa1-6 orthotopic models. a Inhibitory effects of VEGF antibody, PF-04217903 alone, and their combination on HCC growth and intrahepatic metastasis in the hepa1-6 orthotopic models. Tumor volumes and numbers of tumor foci in the orthotopic implantation models were measured and quantified. b-c The expression levels of EMT markers in HCC tissues detected by IHC and Western blot after VEGF and/or MET signaling inhibition. d-e The effects of VEGF and/or MET inhibition on tumor vascularity (CD34), hypoxia (HIF-1α), MET and P-MET expression detected by IHC and Western blot. Data are shown as the mean ± SD. Significant differences were determined using one-way ANOVA. *: P < 0.05; **: P < 0.01; NS: No Significance