Table 3 Drug sensitivities in monolayer culture system, tumor spheroids, and multicellular tumor spheroids (MCTSs) of patient-derived cells
Cells | Spheroid formation | Drug sensitivity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Monolayer culture | Tumor spheroids | MCTS | ||||||||
5-FU | Cis | Sor | 5-FU | Cis | Sor | 5-FU | Cis | Sor | ||
103209 | Compacted spheroid | ++ | – | – | – | – | – | + | – | + |
101509 | Compacted spheroid | + | + | – | + | – | – | + | – | – |
116261 | Compacted spheroid | ++ | + | – | – | – | – | – | – | – |
8513B | Loosely compacted aggregates | + | – | – | ++ | + | – | – | – | – |
51532B | Loosely compacted aggregates | + | + | – | ++ | + | + | + | – | ++ |
21612B | Compacted spheroid | + | – | – | – | – | – | – | – | – |
35372B | Compacted spheroid | + | – | – | ++ | – | + | + | + | – |
27273B | Compacted spheroid | ++ | – | – | + | + | – | + | – | – |