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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma

Fig. 1

Screening for potential hypermethylated genes in NPC. The Venn diagram indicates intersected 326 genes that are both hypermethylated in NPC cells with relative methylated DNA enrichment ≥1.5-fold in C666.1 compared with that of NP69 (1161 genes) and downregulated at least 1.3-fold in nine NPC tumors (T) compared with pooled adjacent normal tissues (N) (8447 genes). The intersected genes were analyzed by MetaCore™ GeneGo pathway analysis. The top three significant pathways are listed. The bottom table shows the relative methylated DNA enrichment and the expression fold-change of the four genes involved in the tight junction pathway

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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