Fig. 1
From: MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling
Expression of miR-760 was decreased in colorectal cancer tissues and cell lines. a Thirty-five miRNAs were differentially expressed between normal and cancer samples with available miRNA data in the TCGA database. b Real-time PCR analysis of miR-760 expression in paired fresh tissues from 76 CRC patients. Average miR-760 expression was normalized using U6 expression. ***P < 0.001. c Samples were divided according to their Dukes stage and the expression of miR-760 in CRC tissues was analyzed. d Expression profiling of miRNAsreveals that miR-760 is lower in tumor tissues compared with normal tissues (n = 441, P < 0.0001; TCGA). e Overall survival of 76 CRC patients who was stratified based on low expression (<median, n = 38) and high expression (>median, n = 38) of miR-760. miR-760 downregulation was significantly correlated with poor overall survival (P < 0.01). Error bar represents the mean ± SD of three independent experiments. ***P < 0.001, ****P < 0.0001