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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling

Fig. 7

The relationships between miR-760 expression and the expression of BATF3 in human CRC tissue. a BATF3 expression in fixed CRC tissues was examined using immunohistochemistry. Representative images are shown (× 200). b Patients with high miR-760 expression had significantly lower BATF3 expression compared with those with low miR-760 expression (P < 0.001). c miR-760 was inversely associated with intratumoral BATF3 expression (r2 = 0.68, P < 0.001). d Real-time PCR analysis of BATF3 expression in 20 paired CRC tissues. e Representative images of BATF3 staining are shown in CRC tissues and matched normal tissues (× 200). f Overall survival of patients with CRC cancer was stratified according to low expression (<median, n = 40) and high expression (>median, n = 40) of BATF3. BATF3 upregulation was significantly correlated with poor overall survival (P = 0.02). g Schematic diagram of the proposed molecular mechanismby which miR-760 modulates CRC cell proliferation

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