Fig. 2

A schematic model illustrating the relationship between glucose metabolism and radiation resistance. Radiation-resistant cells exhibit an active glycolytic phenotype, and the enzymes in the glycolytic pathway play an important role in the process of radioresistance and can serve as targets for improving the efficacy of radiotherapy. In addition, HIF is able to activate glycolytic enzymes and promote the occurrence of radioresistance by inducing cell autophagy and angiogenesis. * was used to represent the targets to enhance radiosensitivity, the corresponding radiosensitizers are indicated in the same color in rectangle