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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

Fig. 4

JNK inhibitor and shRNA-c-JUN remarkably attenuated LOXL2 expression and JNK/c-JUN pathway activation in HCC cells grown on higher stiffness substrate. (a) A co-inhibitor of JNK and integrin β obviously decreased phosphorylation levels of JNK and c-JUN and expression of LOXL2 as compared with JNK inhibitor alone or integrin β1 alone. (b) Knockdown of c-JUN inhibited LOXL2 expression significantly in MHCC97H and Hep3B cells grown 16 KPa stiffness substrate. Error bar represents SEM, *p < 0.05, **p < 0.01 and ***p < 0.001

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