Fig. 6

(a) shows changes in the tumor volume of the subcutaneous xenograft tumor in experimental groups. (b) The tumor volume in combination group was the smallest among the experimental groups. (c) The tumor weight in combination group was smaller than that in other groups. (d) There was no significant difference of weight in all experimental groups. (e) Western blot analysis shown the expression of proteins related to MDM-p53 signal pathway and DNA damage in xenograft tumor model (MKN45). (f) The expression of p53, MDM2, p21, PUMA and Ki67 in experimental tumors. (g) Quantification of the proliferation index in the tumor sections