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Table 1 The IC50 of APG-115 in six gastric cancer cell lines with different p53 status

From: A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

Cell lines p53 Status IC50 for APG-115 (nM)
AGS Wild-type 18.9 ± 15.6
MKN45 Wild-type 103.5 ± 18.3
BGC-823 deletion > 10,000
SGC-7901 deletion > 10,000
N87 Mutation > 10,000
NUGC-3 Mutation > 10,000