Table 3 Relationship between protein expressions in breast cancer patients
From: NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma
cNHERF1 | nNHERF1 | mNHERF1 | cVEGF | cVEGRF1 | MVD | nHIF-1 α | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | ||
n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||||
nNHERF1 | ||||||||||||||||||||||
Negative | 51(42.9) | 22(73.3) | 0.003 | ` | ||||||||||||||||||
Positive | 68(57.1) | 8(26.7) | ||||||||||||||||||||
mNHERF1 | ||||||||||||||||||||||
Negative | 56(43.4) | 17(85.0) | 0.001 | 107(82.9) | 12(60.0) | 0.017 | ||||||||||||||||
Positive | 73(56.6) | 3(15.0) | 22(17.1) | 8(40.0) | ||||||||||||||||||
cVEGF | ||||||||||||||||||||||
Negative | 39(66.1) | 27(34.2) | < 0.001 | 40(67.8) | 72(91.1) | 0.001 | 45(76.3) | 75(94.4) | 0.001 | |||||||||||||
Positive | 20(33.9) | 52(65.8) | 19(32.2) | 7(8.9) | 14(23.7) | 4(5.1) | ||||||||||||||||
cVEGFR1 | ||||||||||||||||||||||
Negative | 40(58.8) | 32(40.5) | 0.027 | 54(79.4) | 63(79.7) | 0.960 | 56(82.4) | 71(89.9) | 0.185 | 37(54.4) | 27(35.1) | 0.019 | ||||||||||
Positive | 28(41.2) | 47(59.5) | 14(20.6) | 16(20.3) | 12(17.6) | 8(10.1) | 31(45.6) | 50(64.9) | ||||||||||||||
MVD | ||||||||||||||||||||||
Negative | 32(47.1) | 38(50.0) | 0.724 | 56(82.4) | 59(77.6) | 0.481 | 57(83.8) | 68(89.5) | 0.317 | 28(41.8) | 36(47.4) | 0.503 | 41(58.6) | 31(38.3) | 0.013 | |||||||
Positive | 36(52.9) | 38(50.0) | 12(17.6) | 17(22.4) | 11(16.2) | 8(10.5) | 39(58.2) | 40(52.6) | 29(41.4) | 50(61.7) | ||||||||||||
nHIF-1α | ||||||||||||||||||||||
Negative | 36(40.4) | 32(60.4) | 0.021 | 78(87.6) | 34(64.2) | 0.001 | 81(91.0) | 42(79.2) | 0.046 | 34(37.8) | 28(54.9) | 0.049 | 49(51.6) | 22(40.0) | 0.171 | 44(48.9) | 23(42.6) | 0.463 | ||||
Positive | 53(59.6) | 21(39.6) | 11(12.4) | 19(35.8) | 8(9.0) | 11(20.8) | 56(62.2) | 23(45.1) | 46(48.4) | 33(60.0) | 46(51.1) | 31(57.4) | ||||||||||
nTWIST1 | ||||||||||||||||||||||
Negative | 18(29.0) | 39(57.4) | 0.001 | 56(90.3) | 49(72.1) | 0.008 | 58(93.5) | 56(81.2) | 0.035 | 21(32.8) | 35(54.7) | 0.013 | 33(50.0) | 32(45.7) | 0.617 | 31(49.2) | 31(44.9) | 0.623 | 51(78.5) | 34(50.7) | 0.001 | |
Positive | 44(71.0) | 29(42.6) | 6(9.7) | 19(27.9) | 4(6.5) | 13(18.8) | 43(67.2) | 29(45.3) | 33(50.0) | 38(54.3) | 32(50.8) | 38(55.1) | 14(21.5) | 33(49.3) | ||||||||