Fig. 2
Expression levels and PCA analysis of serum miR-22 and let-7c/miR-99a/−125b cluster in a cohort of DLBCL patients. a Box-plot diagrams of relative miRNA expression levels in pre-treatment and post-treatment serum samples from DLBCL patients. Boxes define the 25th and 75th percentiles; the horizontal line into the boxes indicates the median, and bars define the minimum and maximum values. The expression levels of mature miRNAs were normalized to volume and UniSp2 spike-in RNA. p-values were determined using the Mann–Whitney rank sum test. b Principal Component Analysis plots for pre- and post-treatment samples considering the combination of miR-22, let7c and miR-99a serum levels