Fig. 6
The effects of Chibby and PDK1 on Wnt/β-catenin signaling-induced NPC cell proliferation. a Knockdown of PDK1 diminished the promoting effect of β-catenin on cell proliferation in CNE1 cells. b Cell proliferation rates were measured in CNE1 cells following overexpression of β-catenin, Chibby, PDK1, alone or in combination. c, d Representative photograph and tumor growth curve of CNE1 xenografts in nude mice. 4 × 106 cells of CNE1 were injected subcutaneously into mice. Tumor growth was monitored regularly for 7 weeks, then the tumor volume was calculated every week. Data were expressed as the mean ± SD, n = 6 for each group. *, p < 0.05; **, p < 0.01