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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: LncMAPK6 drives MAPK6 expression and liver TIC self-renewal

Fig. 1

Overexpression of MAPK6 in liver tumor and TICs. (a) Expression profiles of MAPK components were shown as heatmap. Blue denoted low expression and red denoted high expression. (b) MAPK6 is highly expressed in liver cancers. (c) According to MAPK6 expression, HCC samples were divided into two groups (MAPK6high and MAPK6low) for Kaplan–Meier survival analysis. (d) MAPK6 expression were examined in 19 peri-tumor samples, 7 early HCC samples (eHCC) and 12 advanced HCC samples (aHCC), and all the results were normalized to the average of peri-tumor expression. (e) Immunohistochemistry of MAPK6 in peri-tumor, eHCC and aHCC. Representative images and indicated ratios were shown. (f, g) MAPK6 mRNA expression in CD133+ liver TICs (f) or oncospheres (g) was examine with realtime PCR. RNA expression levels were normalized to MAPK6 expression in non-TICs. For b, data were presented as box and whisker plot, boxes represent interquartile ranges (IQR)

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