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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma

Fig. 5

The effect of co-treatment of olaparib and doxorubicin on the proliferation of osteosarcoma cells. a Co-treatment of the PARP inhibitor, olaparib, and doxorubicin significantly inhibited the growth of U2OS, SaOS2, MG63, and KHOS/NP cells compared with individual treatment of olaparib or doxorubicin in MTT and colony forming assay. b Soft agar assay showed significantly decreased proliferation of U2OS, SaOS2, and MG63 cells with co-treatment of 10 μM of olaparib and 0.2 μM of doxorubicin (magnification, × 100). *, versus control, P < 0.05; **, versus control, P < 0.001; †, versus doxorubicin, P < 0.05; ††, versus doxorubicin, P < 0.001

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